NAD Triple Boost™ Ultra - 500 mg Niagen, 30 capsules

NAD Triple Boost Ultra combines clinically effective Niagen® Nicotinamide Riboside with a variety of other longevity-promoting nutrients such as apigenin, quercetin, PQQ, panax ginseng, and tryptophan to optimize NAD+ levels from every angle.

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NAD Triple Boost

• Enhances longevity by actively increasing NAD+ levels
• Defends against accelerated NAD+ decline
• Activates sirtuins to enhance healthspan
• Aids in the removal of senescent cells
• Promotes heart function by supporting healthy blood flow
• Protects the brain from age-related decline
• Supports healthy methylation patterns

Research-Supported Benefits:

Promotes Longevity by Increasing NAD+. NAD Triple Boost Ultra promotes longevity by increasing NAD+ levels through a variety of different pathways within the body.

• NR functions as an NAD+ precursor and has been shown to significantly increase NAD+ levels in the body. (1)
  
• Apigenin works synergistically to increase NAD+ levels by inhibiting the activity of the CD38 enzyme, which is an NAD+ consuming enzyme that has been shown to significantly decrease NAD+ levels when overexpressed. (2)
  
• Tryptophan plays a subtle, yet important role in increasing NAD+ through the De Novo Synthesis Pathway, which is an alternative NAD+ creation process that works differently than NAD+ precursors to increase NAD+ levels (3)
  
• Panax Notoginseng Extract in NAD Triple Boost Ultrais rich in ginsenosides, which have been shown to improve NAD+ levels when combines with NAD+ precursor supplements. (4)
  
• PQQ acts as a sirtuin activator and reduces oxidative stress, two additional important factors for supporting healthy NAD+ levels. (5)
  
• Quercetin acts as a sirtuin activator like PQQ, with the additional benefit of aiding in the removal of senescent cells from the body. (6) Senescent cells secrete inflammatory compounds that increase the expression of the CD38 enzyme, reducing NAD+ levels in healthy cells. (7)

Improves Cellular Health. NAD Triple Boost Ultra supports cellular health through several mechanisms. By increasing NAD+ levels, NAD Triple Boost Ultra enhances the body’s ability to repair damaged DNA. (8) Additionally, the apigenin, PQQ, and quercetin contained in NAD Triple Boost Ultra act as powerful antioxidants to reduce oxidative stress, a key contributor to accelerated cellular aging. (9)

Enhances Heart Health. The synergistic effects of the nutrients in NAD Triple Boost Ultra offer significant protection against cardiac aging. NR and quercetin promote healthy artery function and have been shown to aid in blood pressure regulation, while PQQ further enhances heart health by improving mitochondrial function in heart cells. (10, 11)

Protects Against Cognitive Decline. Maintaining youthful NAD+ levels is critical to reduce age-related cognitive decline. Research shows increasing NAD+ levels shows promise in supporting healthy brain aging and enhancing cognitive function. (12)

Supports Healthy Methylation. The methylation process is an important process within the body that plays roles in detoxification, liver function, neurotransmitter production, and longevity. Some researchers believe that supplementing with NAD+ precursors may reduce the amount of methyl donor nutrients in the body, increasing the need to replenish methyl donor nutrients to support the methylation process. Some B-vitamins, like the vitamin B12 (methylcobalamin) found in NAD+ Triple Boost Ultrasupport healthy methylation patterns by promoting SAMe production, a key methyl donor that participates in methylation reactions throughout the body. (13)

References:

1. Fang EF, Lautrup S, Hou Y, et al. NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends Mol Med. 2017;23(10):899-916. doi:10.1016/j.molmed.2017.08.001

2. Sharma A, Chabloz S, Lapides RA, Roider E, Ewald CY. Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients. 2023;15(2):445. Published 2023 Jan 14. doi:10.3390/nu15020445

3. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-141. doi:10.1038/s41580-020-00313-x

4. Bai LB, Yau LF, Tong TT, Chan WH, Zhang W, Jiang ZH. Improvement of tissue-specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol. Pharmacol Res Perspect. 2022;10(4):e00986. doi:10.1002/prp2.986

5. Zhang J, Meruvu S, Bedi YS, et al. Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells. Nutr Res. 2015;35(9):844-849. doi:10.1016/j.nutres.2015.06.014

6. Kirkland JL, Tchkonia T. Senolytic drugs: from discovery to translation. J Intern Med. 2020;288(5):518-536. doi:10.1111/joim.13141

7. Chini C, Hogan KA, Warner GM, et al. The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline. Biochem Biophys Res Commun. 2019;513(2):486-493. doi:10.1016/j.bbrc.2019.03.199

8. Wilk A, Hayat F, Cunningham R, et al. Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity. Sci Rep. 2020;10(1):651. Published 2020 Jan 20. doi:10.1038/s41598-020-57506-9

9. Warraich UE, Hussain F, Kayani HUR. Aging - Oxidative stress, antioxidants and computational modeling. Heliyon. 2020;6(5):e04107. Published 2020 May 31. doi:10.1016/j.heliyon.2020.e04107

10. Bonarjee VVS. Arterial Stiffness: A Prognostic Marker in Coronary Heart Disease. Available Methods and Clinical Application. Front Cardiovasc Med. 2018;5:64. Published 2018 Jun 11. doi:10.3389/fcvm.2018.00064

11. Serban MC, Sahebkar A, Zanchetti A, et al. Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2016;5(7):e002713. Published 2016 Jul 12. doi:10.1161/JAHA.115.002713

12. Lee HJ, Yang SJ. Supplementation with Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice. Int J Mol Sci. 2019;20(17):4196. Published 2019 Aug 27. doi:10.3390/ijms20174196

13. Vaccaro JA, Naser SA. The Role of Methyl Donors of the Methionine Cycle in Gastrointestinal Infection and Inflammation. Healthcare (Basel). 2021;10(1):61. Published 2021 Dec 29. doi:10.3390/healthcare10010061