Sirtuin 6 Activator - 60 capsules

Sirtuin 6 Activator: Inspired by the Blue Zones

• Activates sirtuin 6 (SIRT6)^1,4,6,7*
• Provides “Blue Zone” bioactives*^5,6
• Supports multiple longevity pathways*⁵
• Neutralizes free radicals*^5,12
• Supports a healthy immune system & inflammatory response* ^8,5,9-11

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Not all fucoidan is created equal. After three years of extensive research and testing, we've finally sourced an authentic Fucus vesiculosus—a special type of seaweed championed by Dr. Vera Gorbunova, Professor of Biology at the University of Rochester and Co-Director of the Rochester Aging Research Center. Renowned for its powerful fucoidan content and abundant marine polyphenols, this premium seaweed extract sets a new benchmark in longevity science.* ^{2,5,8,13,21,22,25}

What Makes Ours Better?

• Fucoidan-Rich Seaweed: We deliver pure, concentrated seaweed—not synthetic compounds or low-quality extracts—packed with fucoidan, a potent SIRT6 activator.*^21,22 
  
• Longevity Boost: Each serving provides a full 400mg dose of fucoidan, the scientifically-backed compound for healthy aging.*
  
• Full Spectrum Support: Our formula blends whole-plant seaweed powder with high-potency extracts, offering a more complete range of bioactive compounds to amplify fucoidan’s anti-aging potential.*^12,15
  
• Maximized Bioactivity: Unlike many seaweed extracts that lose potency through harsh processing, our fucoidan is gently extracted using a specialized water-based method, preserving its full molecular structure for optimal effectiveness.*⁵
  

Why Choose ProHealth?

• Doctor-Formulated: Developed by our in-house science team in collaboration with leading wellness experts to address the root causes of aging.*
  
• Triple Lab Tested: Subjected to three rounds of independent third-party lab testing to ensure unmatched potency and purity.
  
• Full Transparency: In an industry full of misleading claims, we publish our third-party lab results—so you always know exactly what’s in every bottle.
• Manufactured in the USA: Made in FDA-regulated, GMP-certified facilities, adhering to the highest quality and safety standards.
• 100-Day Risk-Free Guarantee: We’re confident you’ll love our product. If you’re not satisfied, contact our Santa Barbara, CA office for a full refund within 100 days—no hassle, no questions asked.

Not all fucoidan is created equal.

For centuries, Japan—home to one of the world’s longest-living populations—has relied on seaweed as a dietary staple, prized for its powerful antioxidants and cellular-protective compounds. Research consistently links regular seaweed consumption to enhanced health and longevity, reinforcing its vital role in healthy aging.*¹⁵

Building on this tradition, Sirtuin 6 Activator delivers fucoidan, one of seaweed’s most potent bioactive compounds. Naturally found in the cell walls of brown seaweed, fucoidan is clinically recognized for its ability to activate SIRT6, a key enzyme that supports healthy aging at the cellular level.*¹

By activating SIRT6, this fucoidan-rich formula goes beyond simple antioxidant support to revitalize cellular health at its core. Research shows that increased SIRT6 activity can aid in DNA repair, boost genomic stability, and support a healthy systemic inflammatory response—processes linked to longevity in Blue Zone populations.*^{5,8,9,12,14,16}

Emerging studies further suggest that higher SIRT6 activity correlates with longer lifespans in multiple animal species. Scientists are now exploring its potential for brain aging, heart health, and overall longevity, with human trials underway to further uncover its impact on healthy aging.*^20,26-28

Sirtuin 6 Activator: Inspired by the Blue Zones

Aging is associated with cellular changes, including DNA damage, inflammation, and metabolic shifts, all of which have been studied in relation to SIRT6’s biological functions. Research suggests that SIRT6 plays a role in key cellular processes that support overall health.*

• Supports DNA Repair – SIRT6 stabilizes the genome by repairing double-strand breaks and maintaining telomere integrity, reducing genetic instability, a major hallmark of aging.*⁶
• Influences Metabolic Balance – SIRT6 shifts cells away from inefficient sugar metabolism and toward fat oxidation, mimicking the anti-aging effects of caloric restriction.*¹⁷
• Clears Senescent Cells – Fucoidan acts as a potential senolytic, helping the body remove dysfunctional cells that drive aging.*^4,13,19
• Protects Mitochondria – SIRT6 supports healthy cellular energy production, safeguarding from oxidative stress so cells can generate energy efficiently.*⁵

Neutralizes Free Radicals*

Oxidative stress occurs when free radicals accumulate and damage cells, proteins, and DNA—a primary driver of aging. ProHealth Sirtuin 6 Activator combats oxidative damage through multiple pathways:

• Directly Scavenges Free Radicals – Fucoidan’s unique sulfated polysaccharide structure binds to and neutralizes reactive oxygen species (ROS) before they can harm cells.*¹²
• Provides Antioxidant Support – This formula combines fucoidan with polyphloroglucinols, marine polyphenols that strengthen cellular defenses against oxidative damage.*⁵
• Enhances Cellular Antioxidant Pathways – By enhancing glutathione and superoxide dismutase (SOD) levels, SIRT6 supports the body’s natural ability to maintain oxidative homeostasis.*¹²

Supports a Healthy Immune System & Inflammatory Response*

Healthy immune system and inflammatory responses are essential for long-term health and longevity. Research suggests that fucoidan and SIRT6 may help support immune function and inflammation balance through multiple pathways:

• Supports Immune Cell Activity – Fucoidan supports the activity of macrophages, natural killer (NK) cells, and lymphocytes, helping to maintain a robust immune system and clear damaged cells.*^5,8,10
• Helps Maintain a Healthy Inflammatory Response – SIRT6 influences cytokine activity and inflammatory response mechanisms, helping to support healthy inflammation for optimal aging.* ^5,8,9
• Enhances Gut-Immune Function – Fucoidan supports a healthy gut microbiome, which is closely linked to immune and inflammatory balance.*¹¹

Order now and join the 200,000+ people who trust ProHealth Sirtuin 6 Activator for their cellular health!

Ingredients:

• Brown Seaweed (Fucus vesiculosus): A rich source of fucoidan, a bioactive polysaccharide recognized for supporting cellular health and activating SIRT6, the longevity enzyme.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

¹ Rahnasto-Rilla M et al. Mar Drugs. 2017;15(6):190. 
² Kawaguchi T et al.  Int J Oncol. 2015;46(5):2216-2222.
³ Yu W et al. Mol Nutr Food Res. 2017;61(10):1700136.
⁴ Cao L et al. Mar Drugs. 2020;18(11):564.
⁵ Li B et al. Molecules. 2008;13(8):1671-1695. 
⁶ López-Otín C et al. Cell. 2023;186(2):243-278.  
⁷ Iso H et al. Nutrition and disease in the JACC study. 
⁸ Jayawardena TU et al. Mar Drugs. 2022;20(12):755. 
⁹ Apostolova E et al. Polymers. 2020;12(10):2338.
¹⁰ Bogolitsyn K et al. Plant Foods Hum Nutr. 2024;79(2):511-517.
¹¹ Luthuli S et al. Mar Drugs. 2019;17(9):487.  
¹² Catarino MD et al. Mar Drugs. 2018;16(8):249.
¹³ Zhang L  et al. Innov Aging. 2022;6(Suppl 1):130.
¹⁴ Myers S et al. Biol Targets Ther. 2011;45.
¹⁵ Myers S. Biol Targets Ther. 2010;33. 
¹⁶ Li X et al. Front Cell Dev Biol. 2021;9:641315. 
¹⁷ Zhang N et al. Cell Cycle. 2016;15(7):1009-1018.  
¹⁸ Chilton WL et al. PLoS ONE. 2014;9(4):e92088. 
¹⁹ Akter R  et al. Int J Mol Sci. 2021;22(8):4180.
²⁰ Zhang L et al. Innov Aging. 2022;6(Suppl 1):130. 
²¹ Gorbunova V. Mechanisms of longevity: Lessons from long-lived mammals. Foresight Institute Seminar. 2020.
²² Kawamura A et al. Mar Drugs. 2021;19(8):452.
²³ Willcox DC et al. Ann NY Acad Sci. 2009;1173:126-138. 
²⁴ Buettner D. National Geographic. 2015.  
²⁵ Korotkov A et al. Trends Cell Biol. 2021;31(12):994-1006. 
²⁶ Zhang L et al. Oxid Med Cell Longev. 2019;2019:8918914.
²⁷ Yang J et al. Int J Biol Macromol. 2024;277(Pt 3):134397.
²⁸ Wang K et al. Ther Adv Chronic Dis. 2022;13:20406223221076891.