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In a randomized controlled trial, eating 45% of daily calories at breakfast, instead of 45% at dinner, led to significantly less hunger during the day.
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Although there was no difference in weight loss (possibly due to the short study), the morning-loaded intake (big breakfast) may assist with compliance to weight loss regime through a greater suppression of appetite.
This study was published in Cell Metabolism: [study excerpt]
Morning loaded calorie intake in humans has been advocated as a dietary strategy to improve weight loss. This is also supported by animal studies suggesting time of eating can prevent weight gain.
However, the underlying mechanisms through which timing of eating could promote weight loss in humans are unclear. In a randomized crossover trial (NCT03305237), 30 subjects with obesity/overweight underwent two 4-week calorie-restricted but isoenergetic weight loss diets, with morning loaded or evening loaded calories (45%:35%:20% versus 20%:35%:45% calories at breakfast, lunch, and dinner, respectively).
We demonstrate no differences in total daily energy expenditure or resting metabolic rate related to the timing of calorie distribution, and no difference in weight loss. Participants consuming the morning loaded diet reported significantly lower hunger. Thus, morning loaded intake (big breakfast) may assist with compliance to weight loss regime through a greater suppression of appetite.