Experience the Power of NMN: What to Expect When You Start Supplementing

Nicotinamide Mononucleotide (NMN) has been gaining increasing attention in the world of health and wellness. The reason? Its potential to improve health and lifespan. But what does it actually feel like to take NMN? We've gathered information from people who have tried it, including the ProHealth team, doctors, patients, and users just like you to paint a clear picture of what you can expect when you start supplementing with NMN.

What is NMN?

NMN stands for Nicotinamide Mononucleotide, a molecule naturally occurring in our bodies and in certain foods. This molecule is a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme that plays an essential role in virtually all biological processes, including energy production, DNA repair, and cellular communication. While that might sound a little vague and straight out of a biochemistry textbook, it has real implications for how you feel on a daily basis – and it’s something you can change.

NMN and NAD+: A Vital Relationship

It's important to understand that NMN is a precursor to NAD+. This means that NMN is used by our bodies to produce NAD+. Why does this matter? Because NAD+ is essential for the proper functioning of our cells. Unfortunately, NAD+ levels naturally decline as we age, leading to a variety of age-related health issues. This is where NMN comes in. By supplementing with NMN, we can potentially boost our NAD+ levels, thereby improving various aspects of our health, and more studies are being published supporting this.

What to Expect When You Start Taking NMN

Immediate Effects

NMN supplementation is often associated with a noticeable increase in energy levels, typically observed within a few hours after consumption. This is linked to the role of NAD+ in cellular metabolism. NMN is converted to NAD+ in the body, a coenzyme in the mitochondria, the cell's energy-producing organelles. NAD+ is involved in the electron transport chain, which leads to the formation of adenosine triphosphate (ATP), the molecular currency of cellular energy. Consequently, an increase in NAD+ levels potentially fast-tracks ATP production, accounting for the feeling of elevated energy.

Secondly, many users report enhanced mental clarity and focus shortly after taking NMN, much like a nootropic. NAD+ plays a significant role in neural function. It is involved in the maintenance of the DNA in neurons, the cells responsible for cognitive function. DNA integrity is critical for cellular function, including in neurons where it has an impact on synaptic plasticity. Synaptic plasticity is the ability of synapses to strengthen or weaken over time, which is essential for learning and memory. An increase in NAD+ could enhance neural function, translating to improved mental clarity and focus in both the short and long term, and the additional ATP production in neurons powers faster thought and memory recall.

NAD+ also has a role in neuroprotection. It serves as a substrate for various enzymes like PARPs (Poly (ADP-ribose) polymerases) and sirtuins, which have neuroprotective effects. These enzymes are involved in DNA repair and the regulation of oxidative stress, which is vital for maintaining cognitive function. Thus, an increase in NAD+ levels could potentially support these neuroprotective actions, further contributing to the immediate feelings of mental acuity over time.

Some people who are new to taking NMN or have sensitive digestive systems may feel some discomfort when taking NMN. Most people find that taking NMN with a meal resolves this discomfort. This has the additional advantage of slowing the absorption of NMN for a potentially more prolonged, though less pronounced, effect.

Short-Term Effects (Your First 30 Days)

After about 30 days of consistent NMN supplementation, you’ll start to feel the real benefits of NMN. These range from improved sleep quality and better mood to increased physical endurance, each underpinned by biological mechanisms related to NAD+.

Sleep Quality

Improved sleep quality is a frequently cited benefit. Users often find it easier to both fall asleep and maintain uninterrupted sleep. The explanation for this could lie in the role NAD+ plays in regulating circadian rhythms. The circadian clock, which controls our sleep-wake cycles, is modulated by a series of biochemical reactions involving NAD+. Maintaining high levels of NAD+ can contribute to a more balanced and efficient circadian rhythm, which in turn can lead to better sleep quality.

Mood Enhancement

Many individuals also report experiencing a calmer and more positive mood after a few weeks of NMN supplementation. NAD+ contributes to the overall health and function of the brain, including neurotransmitter regulation. Serotonin and dopamine, neurotransmitters linked to mood, could be positively affected by increased NAD+ levels. These neurotransmitters are synthesized and broken down in pathways that require NAD+ as a coenzyme, suggesting that balanced levels may lead to mood stabilization.

Physical Endurance

Increased physical endurance is another notable short-term effect. This can be attributed to NAD+'s role in energy production within muscle cells. Just as in any other cell, NAD+ in muscle cells is critical for the production of ATP. During physical exertion, ATP is consumed to fuel muscle contractions. A possible increase in NAD+ levels could accelerate ATP replenishment rates, thereby enhancing endurance and reducing fatigue during physical activities.

Decreased Joint and Muscle Pain

Another notable short-term effect reported by some individuals within the first 30 days of consistent NMN supplementation is a decrease in joint and muscle pain. This is particularly significant for those who engage in frequent physical activity or suffer from conditions associated with inflammation. The potential reason for this relief might lie in the role NAD+ plays in regulating inflammation at the cellular level.

Inflammation is a complex biological response to injury or damage, and while it is a necessary process for healing, excessive inflammation can contribute to pain and discomfort in muscles and joints. NAD+ has been shown to be involved in the activation of certain proteins that can regulate inflammation, such as sirtuins. These proteins help manage the body’s inflammatory response, keeping it in check and possibly reducing excessive inflammation when it is not beneficial.

Moreover, increasing the NAD+ that is fed to mitochondria can improve the function of this energy-producing organelle. Improved mitochondrial function can lead to better cellular recovery, which is essential in muscle and joint tissues that have been stressed or damaged. This efficient recovery process could further contribute to reduced sensations of pain and discomfort.

Long-Term Effects

Over the course of several months to a year of consistent NMN supplementation, a variety of long-term benefits are often reported, encompassing improvements in skin health, eye health, and broader markers of healthy aging. These effects, like the short-term ones, are closely linked to the cellular roles of NAD+.

Skin Health

One of the most commonly reported long-term benefits is enhanced skin health, with users noting healthier, more youthful-looking skin. This is likely because NAD+ is vital for cellular health and repair processes. Skin cells, like all other cells, require NAD+ for DNA repair, as well as for the production of collagen and elastin, proteins that contribute to skin’s elasticity and firmness. By promoting cellular repair and protein synthesis, NAD+ may play a role in slowing down the visible signs of skin aging.

Eye Health

Another area where long-term NMN supplementation can have an impact is eye health. Reports of improved vision may be attributed to the role NAD+ plays in maintaining the health of photoreceptor cells in the eyes. These cells are responsible for capturing light and transforming it into electrical signals that the brain interprets as vision. NAD+ is crucial for the energy metabolism in these highly active cells, potentially contributing to sustained or improved eye health.

Signs of Healthier Aging

Lastly, long-term NMN supplementation is often associated with broader indicators of healthy aging. This can manifest in various ways, from improved mobility to enhanced cognitive function and a general sense of well-being. For instance, NAD+ has been shown to support neuronal health, which could contribute to cognitive longevity. Likewise, the molecule plays a role in muscle function and energy metabolism, potentially leading to improved mobility and physical capability as one ages.

The long-term effects of NMN appear to be an extension of its shorter-term impacts, all rooted in the biological functions of NAD+. These effects—ranging from cellular repair and metabolic support to the sustenance of various tissue types—point to a complex and multifaceted role for NAD+ in supporting overall health. While many of these benefits are reported anecdotally, they are increasingly the subject of scientific investigation with promising initial results.

How to Take NMN

NMN can be taken in various forms, including capsules and powders. The recommended dosage can vary depending on your age and overall health. However, a common dosage is between 250 mg and 1000 mg per day. It's generally recommended to start with a lower dosage and gradually increase it over time.

To ensure a steady supply of NMN in your body, it's often suggested to split your daily dosage into two parts: one in the morning and one in the afternoon. Since some people experience a greater surge of energy than others, avoid taking NMN right before bed, to avoid sleeplessness.

Final Thoughts

NMN supplementation holds promising potential for supporting healthy aging and overall well-being. If you're considering adding NMN to your health regimen, it's important to remember that everyone's experience can differ. Keep in mind that while some effects may be noticed shortly after starting NMN, others may take longer to manifest. With consistent use, NMN could be a valuable addition to your health and wellness journey, offering a range of benefits that could help you feel your best at any age.

References:

1. Mills KF, Yoshida S, Stein LR, et al. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab. 2016;24(6):795-806. doi:10.1016/j.cmet.2016.09.013
2. Verdin E. NAD⁺ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-1213. doi:10.1126/science.aac4854
3. Imai S ichiro, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014;24(8):464-471. doi:10.1016/j.tcb.2014.04.002
4. Yoshino J, Mills KF, Yoon MJ, Imai S ichiro. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536. doi:10.1016/j.cmet.2011.08.014
5. Stein LR, Imai S ichiro. The dynamic regulation of NAD metabolism in mitochondria. Trends Endocrinol Metab. 2012;23(9):420-428. doi:10.1016/j.tem.2012.06.005
6. Ramsey KM, Yoshino J, Brace CS, et al. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science. 2009;324(5927):651-654. doi:10.1126/science.1171641
7. Kennedy PJ, Cryan JF, Dinan TG, Clarke G. Kynurenine pathway metabolism and the microbiota-gut-brain axis. Neuropharmacology. 2017;112(Pt B):399-412. doi:10.1016/j.neuropharm.2016.07.002
8. Frederick DW, Loro E, Liu L, et al. Loss of nad homeostasis leads to progressive and reversible degeneration of skeletal muscle. Cell Metabolism. 2016;24(2):269-282. doi:10.1016/j.cmet.2016.07.005
9. Houtkooper RH, Cantó C, Wanders RJ, Auwerx J. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev. 2010;31(2):194-223. doi:10.1210/er.2009-0026
10. Lin JB, Kubota S, Ban N, et al. Nampt-mediated nad(+) biosynthesis is essential for vision in mice. Cell Rep. 2016;17(1):69-85. doi:10.1016/j.celrep.2016.08.073
11. Braidy N, Guillemin GJ, Mansour H, Chan-Ling T, Poljak A, Grant R. Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats. PLoS One. 2011;6(4):e19194. doi:10.1371/journal.pone.0019194
12. Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of niagen (Nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep. 2019;9(1):9772. doi:10.1038/s41598-019-46120-z