Older men who took an NMN supplement for 12 weeks had significant increases in markers of physical strength and performance, adding to the evidence that NMN supports muscular health with age.

The NMN transporter Slc12a8 is also found in the lateral hypothalamus, which can regulate the sympathetic nervous system and skeletal muscle function, resulting in healthier aging and energy consumption.  

Differences in an astronaut’s bone response and recovery to microgravity are primarily explained by mission duration, and there may be therapeutic potential of NMN for bone regeneration in astronauts.

Researchers are hopeful that strategies to maintain or increase nitric oxide bioavailability may be a valuable way to prevent age-related disorders and preserve the health of older adults.