Alpha-ketoglutarate (AKG) increases lifespan and reduces age-related markers of frailty in mice, which may impact important elements of human aging and improve quality of life in the elderly population.

Quercetin is a flavonoid that may be neuroprotective — in studies with animals and cell cultures, at least. In this study, quercetin improved memory and reduced oxidative stress and neuroinflammation in aging mice.

Unprecedented trends in population aging are predicted to become an incessant burden on healthcare finances. In this study, long-term NMN administration mitigated age-associated physiological decline in mice.

Berberine is a compound produced by several plants; this study finds low-dose berberine increases lifespan in yeast, mice, and human cells and reverses biomarkers of aging.