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Brain Health
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Blood Sugar SupportFree Nutritional Advisor
Free Nutritional AdvisorHelps combat aging, supports heart health and promotes muscle strength and cognition
- NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, neurological function, heart health and body weight.
- Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that may improves health and longevity by serving as a precursor to NAD+.
- Liposomal form of NMN allows for increased bioavailability and enhanced absorption.
- Liposomal NMN Pro Complete is the first and only perfectly balanced combination of liposomal NMN, Trans-Resveratrol and TMG on the market. Instead of having to take three separate supplements each day, you can now get the ideal balance of all three in one convenient serving.
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Research-Supported Benefits:
Supports Longevity. Studies have shown that boosting NAD+ synthesis in the body extends the lifespan of yeast, worms and flies. (1)Blood Sugar Regulation. As we age, we have more trouble processing glucose, leading to higher blood sugar—a known contributor to several metabolic-related disorders. Supplemental NMN has been shown to improve several markers of skeletal muscle glucose metabolism that are commonly dysregulated in people with metabolic disorders. (2)
Supports Metabolism and Healthy Weight. Although excessive body weight can develop at any age, adults over age 40 are particularly susceptible to age-related weight gain as metabolism slows down and body composition is altered to favor fat over lean muscle. As obese individuals have reductions in both NAD+ levels and ATP (energy) production, replenishing NAD+ through NMN can help to reverse this while improving metabolic pathways to maintain a healthy weight. (3,4,5)
Supports Healthy Cognition: With increasing age, adults experience declining cognitive function, which is often caused by low NAD+ levels and impaired mitochondrial function. Replenishing NAD+ stores through NMN may be able to prevent this dysfunction. (6,7,8,9)
Supports Healthy Skin: In our 30s and 40s, the appearance of our skin can start to show signs of age. Several studies have examined how boosting NAD+ levels in the skin (10, 11)
References
1. Fang EF, Kassahun H, Croteau DL, et al. NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metab. 2016;24(4):566-581. doi:10.1016/j.cmet.2016.09.004
2. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. doi:10.1126/science.abe9985
3. Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022;14(4):755. Published 2022 Feb 11. doi:10.3390/nu14040755
4. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021;18(1):54. Published 2021 Jul 8. doi:10.1186/s12970-021-00442
5. Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536. doi:10.1016/j.cmet.2011.08.014
6. Mills KF, Yoshida S, Stein LR, et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016;24(6):795-806. doi:10.1016/j.cmet.2016.09.013
7. Tarantini S, Valcarcel-Ares MN, Toth P, et al. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019;24:101192. doi:10.1016/j.redox.2019.101192
8. Kiss T, Nyúl-Tóth Á, Balasubramanian P, et al. Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. Geroscience. 2020;42(2):527-546. doi:10.1007/s11357-020-00165-5
9. Wang X, Hu X, Yang Y, Takata T, Sakurai T. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016;1643:1-9. doi:10.1016/j.brainres.2016.04.060
10. Katayoshi T, Nakajo T, Tsuji-Naito K. Restoring NAD+ by NAMPT is essential for the SIRT1/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes. J Photochem Photobiol B. 2021;221:112238. doi:10.1016/j.jphotobiol.2021.112238
11. Feng Z, Qin Y, Huo F, et al. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166287. doi:10.1016/j.bbadis.2021.166287
12. Gopi S, Balakrishnan P. Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (vitamin C) and their enhanced bioavailability. J Liposome Res. 2021;31(4):356-364. doi:10.1080/08982104.2020.1820521
| Supplement Facts | ||
|---|---|---|
| Serving Size: 3 Capsules | ||
| Servings Per Container: 30 | ||
| Amount Per Serving | %DV | |
| Uthever™ β-Nicotinamide Mononucleotide (NMN) (from 1,000 mg Liposomal NMN) |
500 mg | † |
| Micronized Trans Resveratrol (from Japanese (Reynoutria japonica) root) |
500 mg | † |
| Trimethylglycine (TMG) (Betaine Anhydrous) |
250 mg | † |
| † Daily Value not established | ||
- OTHER INGREDIENTS: Sunflower (Helianthus annuus) lecithin, microcrystalline cellulose, vegetable capsule.
- DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, fish, shefillsh, tree nuts, peanuts.
-
SUGGESTED DAILY USE: Take 3 capsules daily, with or without food, or as directed by your healthcare professional.
- CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.
- NOTE: Store in a cool, dryplace, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN.
- ProHealth Longevity’s Liposomal NMN Pro Complete is a trio of longevity-supporting compounds, including NMN, trans-resveratrol and TMG.
- Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that may improve health and longevity by serving as a precursor to NAD+.
- NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, neurological function, heart health, and body weight.
- ProHealth’s Liposomal NMN features an innovative delivery system that may help to increase the product's bioavailability (how well it’s absorbed and used by the body).
- NMN and trans-resveratrol work together, which is why longevity experts recommend taking them together for effectiveness. This dynamic duo has been likened to the operation of a car, with NMN as the fuel and trans-resveratrol as the accelerator pedal.
- Regular resveratrol is composed of 50% trans-resveratrol and 50% cis-resveratrol. Because research suggests that only the trans-form has valuable biological activity, NMN Pro Complete contains pure, natural, pharmaceutical grade trans-resveratrol.
- TMG, also known as betaine, is an amino acid that supports the body's methylation processes. These processes are known to decline with age and may also be affected by common gene variations. Also, NMN supplementation may require the use of methyl groups to help facilitate the conversion of NAD+ in your cells, thereby activating sirtuins and promoting longevity.
- Many top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment your NMN intake. TMG, the choice of many of those experts, is an excellent way to help support your body's ability to maintain an adequate methyl pool.
- Only Clinically-Proven NMN. ProHealth's NMN is the only clinically-proven NMN to boost NAD+ levels in a peer-reviewed, double-blind, placebo-controlled, published clinical study. Results of the study indicated a 38% increase in NAD+ levels and a 12-year reversal in biological age. (12)
- Unique Trio of Longevity-Supporting Ingredients at High Doses. NMN Pro Complete is the first and only perfectly balanced combination of NMN, Trans-Resveratrol and TMG on the market. Instead of having to take three separate supplements each day, you can now get the ideal balance of all three in one convenient serving. A single serving of Liposomal NMN Pro Complete will provide you with 500 mg of NMN from 1,000 mg liposomal NMN, 500 mg of trans-resveratrol, and 250 mg of TMG – the daily dosage most often recommended by the world's leading longevity experts.
- Unique Liposomal Delivery Method. ProHealth’s Liposomal NMN features an innovative delivery system that may help to increase the product's bioavailability (how well it’s absorbed and used by the body).
- Liposomes are nano-sized bubbles with a unique molecular structure that acts as a delivery vehicle to facilitate the transport of NMN into our cells.
- The double-layered bubble safely protects the compound inside, allowing it to travel through the harsh digestive tract and bloodstream until it meets our cells. From there, the liposome merges with our cell membranes and releases the inner nutrient contents into the cell.
- The body recognizes and accepts liposomal structures because they are phospholipid-based, mimicking our own cell membranes. This means compounds can be directly delivered into cells.
- Solvent-Free. Compared to other NMN products, ours is made without any chemical solvents.
- Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
- Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.
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"3rd-party tested, products arrive on time and are in good condition. They’re a trusted brand; they have communicated very well to me in regard to shipping and other areas of interest to me. Their customer service is really amazing; I highly recommend ProHealth products."
- Susan E., Verified ProHealth Longevity Customer