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Brain Health
Cellular Health
Healthy Aging
Heart Health
Free Nutritional Advisor
Free Nutritional AdvisorApigenin is a powerful flavonoid that helps fight the signs of aging and supports numerous aspects of health.
- Supports longevity by inhibiting CD38, a harmful enzyme that decreases NAD+ levels
- Provides antioxidant benefits
- Supports mood, heart and brain health
- Enhances sleep quality
Research-Supported Benefits:
Supports Longevity. Apigenin has been shown to inhibit CD38, a harmful enzyme that decreases NAD+ levels. Inhibition of CD38 helps keep NAD+ levels stable to support healthy aging processes and reduce the risk of premature aging. (1,2)Provides Antioxidant Benefits. The aging process and risk of age-related health issues can be accelerated by free radicals. Antioxidants are a way to help curb free-radical activity. Apigenin’s antioxidant properties have been proven to fight free-radical damage, tackle oxidative stress, reduce signs of premature aging and reduce the risk of age-related health concerns. (3)
Promotes Heart Health. Aging can cause changes to heart function and blood vessels. In fact, adults over the age of 65 are more likely to suffer from a heart event compared to younger people. The most common sign of heart health aging is a change to the arteries, which can become stiff, harden and fill with fat deposits leading to high blood pressure. Apigenin can help decrease certain heart health blood markers, reduce blood pressure and improve blood circulation. (4)
Enhances Sleep Quality. Poor sleep quality is associated with accelerated aging. Research indicates that apigenin has a positive effect on sleep. (5,6)
Supports Brain Health. With aging comes symptoms of brain decline such as impaired memory. Apigenin helps protect the brain from damage caused by oxidative stress, which can lead to a decline in cognitive function. Apigenin may increase cognitive function, improve memory formation and enhance overall mental clarity. (7)
Supports Mood. Studies have shown that apigenin can help reduce feelings of worry, overwhelm, and stress, resulting in improved mood. (8)
Aids in Testosterone Maintenance. Apigenin may support healthy testosterone levels and prevent the decrease in testosterone commonly seen in aging males. (9)
References
1. Escande C, Nin V, Price NL, et al. Flavonoid apigenin is an inhibitor of the NAD+ ASE CD38: Implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609577/. Published April 2013. Accessed February 24, 2023.
2. M; AAZAA. Mitigating effects of apigenin on edifenphos-induced oxidative stress, DNA damage and apoptotic cell death in human peripheral blood lymphocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. https://pubmed.ncbi.nlm.nih.gov/30910686/. Accessed February 24, 2023.
3. Zhang K, Song W, Li D, Jin X. Apigenin in the regulation of cholesterol metabolism and protection of blood vessels. Experimental and therapeutic medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443212/. Published May 2017. Accessed February 24, 2023.
4. Gao, H. L., Yu, X. J., Hu, H. B., Yang, Q. W., Liu, K. L., Chen, Y. M., Zhang, Y., Zhang, D. D., Tian, H., Zhu, G. Q., Qi, J., & Kang, Y. M. (2021). Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus. Cardiovascular toxicology, 21(9), 721–736. https://doi.org/10.1007/s12012-021-09662-1
5. Zhang, K., Song, W., Li, D., & Jin, X. (2017). Apigenin in the regulation of cholesterol metabolism and protection of blood vessels. Experimental and therapeutic medicine, 13(5), 1719–1724. https://doi.org/10.3892/etm.2017.4165
6. Kim, J. W., Kim, C. S., Hu, Z., Han, J. Y., Kim, S. K., Yoo, S. K., Yeo, Y. M., Chong, M. S., Lee, K., Hong, J. T., & Oh, K. W. (2012). Enhancement of pentobarbital-induced sleep by apigenin through chloride ion channel activation. Archives of pharmacal research, 35(2), 367–373. https://doi.org/10.1007/s12272-012-0218-4
7. Dourado, N. S., Souza, C. D. S., de Almeida, M. M. A., Bispo da Silva, A., Dos Santos, B. L., Silva, V. D. A., De Assis, A. M., da Silva, J. S., Souza, D. O., Costa, M. F. D., Butt, A. M., & Costa, S. L. (2020). Neuroimmunomodulatory and Neuroprotective Effects of the Flavonoid Apigenin in in vitro Models of Neuroinflammation Associated With Alzheimer's Disease. Frontiers in aging neuroscience, 12, 119. https://doi.org/10.3389/fnagi.2020.00119
8. Amsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J. A randomized, double-blind, placebo-controlled trial of oral matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. Journal of clinical psychopharmacology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600416/. Published August 2009. Accessed February 24, 2023.
9. Li W, Pandey AK, Yin X, et al. Effects of apigenin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse leydig cells. The Journal of nutritional biochemistry. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939222/. Published March 2011. Accessed February 24, 2023.
10. Li, B. S., Zhu, R. Z., Lim, S. H., Seo, J. H., & Choi, B. M. (2021). Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD[Formula: see text]-CD38 Axis. The American journal of Chinese medicine, 49(5), 1235–1250. https://doi.org/10.1142/S0192415X21500592
11. Ogura, Y., Kitada, M., Xu, J., Monno, I., & Koya, D. (2020). CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats. Aging, 12(12), 11325–11336. https://doi.org/10.18632/aging.103410
12. Salehi, B., Venditti, A., Sharifi-Rad, M., Kręgiel, D., Sharifi-Rad, J., Durazzo, A., Lucarini, M., Santini, A., Souto, E. B., Novellino, E., Antolak, H., Azzini, E., Setzer, W. N., & Martins, N. (2019). The Therapeutic Potential of Apigenin. International journal of molecular sciences, 20(6), 1305. https://doi.org/10.3390/ijms20061305
| Supplement Facts | ||
|---|---|---|
| Serving Size: 2 Capsules | ||
| Servings Per Container: 30 | ||
| Amount Per Serving | %DV | |
| Natural Apigenin (Apium graveolen) Extract 98% |
500 mg | † |
| Organic Parsley Powder (Petroselinum crispum) |
700 mg | † |
| Piperine (Piper nigrum) Black Pepper Extract 95% |
7 mg | † |
| † Daily value not established | ||
- OTHER INGREDIENTS: Vegetable capsule.
- DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts, peanuts.
-
SUGGESTED DAILY USE: Take 2 capsules daily with food, or as recommended by your healthcare professional.
- CAUTION: Do not use if taking hormone therapy. May cause drowsiness at high doses. Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.
- NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN.
- As you age, levels of NAD+, a key nutrient in the body, naturally declines at a rate of 1% per year. Reduced levels of NAD+ contribute to a variety of age-related health concerns including impaired heart health, reduced energy and cognitive decline. Additionally, inflammation, often from unhealthy lifestyle factors, triggers the production of the enzyme CD38, which suppresses NAD+ levels. This further accelerates premature aging and age-related health concerns. Apigenin is proven to help interfere with these processes, supporting overall health and longevity.
- Natural apigenin is the purest form of apigenin and provides longevity and health-supporting benefits.
-
Organic parsley powder promotes the full-spectrum benefits of apigenin, enhancing efficacy due to the naturally containing apigenin co-factors it contains.
- Piperine is added to enhance the absorption of the apigenin. Increased absorption can translate into increased efficacy of the product.
Full-Spectrum Apigenin. Other apigenin products on the market often contain the isolated form of apigenin. This lower-quality version only provides 1-2 health benefits. ProHealth’s Full Spectrum Apigenin contains full-spectrum apigenin to support numerous areas of health and aging. Full spectrum means the entire plant and the full range of flavonoids were used.
Natural Apigenin. The majority of products on the market contain the synthetic version of apigenin. ProHealth’s Full Spectrum Apigenin contains natural apigenin for the highest-quality, most natural version.
Organic Parsley Powder. ProHealth’s Full Spectrum Apigenin contains 700 mg of organic parsley powder, a natural source of apigenin and other co-factors that enhance the biological effects of apigenin.
Better Dosing. Compared to the majority of products on the market with lower doses, Full Spectrum Apigenin contains dosing supported by research: 500 mg natural apigenin, 700 mg organic parsley powder and 7 mg piperine.
Quality-Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.
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