Researchers are hopeful that strategies to maintain or increase nitric oxide bioavailability may be a valuable way to prevent age-related disorders and preserve the health of older adults.

Urolithin A increased muscle strength, improved aerobic endurance, and reduced inflammation in middle-aged adults, likely mediated by boosting NAD+ levels.

Found in broccoli, sulforaphane is a powerful antioxidant compound that supports cardiometabolic and cognitive health by fighting inflammation — but its bioavailability on its own is low.

In older adults with low selenium and coenzyme Q10 levels, supplementation with the two compounds reduced inflammation, oxidative stress, and tissue scarring, thereby supporting heart health.