Omega-3 supplements are a strong contender for fighting the internal signs of aging caused by stress, which could be one way that these healthy fats boost longevity. 

People with Major Depressive Disorder have accelerated internal aging by two years, suggesting that there is an underlying biological mechanism that advances cellular aging in depression.

A lifestyle intervention program including diet, sleep, exercise, relaxation guidance, and probiotics reduced participants' biological age by over three years. 

Supplemental selenium protects against diet-induced obesity in mice and extends lifespan in yeast, likely through the mineral's ability to inhibit a signaling pathway called IGF-1.