Researchers identify chronic inflammation, senescent cells, and activation of the protein CD38 as a driver of NAD+ decline, the crucial coenzyme needed for healthy metabolism, aging, and DNA repair.

The HDAC6 inhibitor Tubastatin A is a promising target to delay or treat osteoarthritis, reversing damage caused by HDAC6 overexpression, protecting the extracellular matrix and chondrocytes.

People with mild cognitive impairment who exercised for at least ten minutes more than once per week had an 18% lower risk of developing Alzheimer's disease compared to non-exercisers.

The APOE4 gene variant is associated with an increased risk of Alzheimer's disease (AD); APOE2 is protective against AD. The APOE2 variant is linked to increased lifespan, irrespective of AD.