NMN supplementation promoted healthier aging in mice by altering the metabolism of amino acids, nucleotides, and NAD+, in addition to lengthening chromosomal ends called telomeres.

Intestinal aging is aggravated by oxidative stress and mitochondrial dysfunction; the antioxidants resveratrol and pterostilbene may be important compounds for combatting these dysfunctions. 

Transplants of fecal matter housing gut microbes from young mice reversed age-related changes in the brain, suggesting that the microbiome may be a suitable target to promote healthy aging.

Gut microbes that break down the amino acid tryptophan secrete small molecules called indoles — and these indoles are a key factor in stimulating new neuron growth in the adult brain.