NMN preserved brain volume, prevented neuronal loss, and improved cellular respiration in brain tissues in this study, providing hope for using NMN as an agent against neurodegeneration. 

Despite all of the advances that longevity research has made in recent years, metabolic changes and dysfunction are an under-studied piece of the aging puzzle.

The breakdown and deterioration of bone known as osteoporosis contributes to increased morbidity and mortality in older adults; NMN may fight or prevent this age-related bone loss.   

Women may have greater cognitive reserves but more accelerated cognitive decline than men, contributing to the greater prevalence of dementia in females in later life.