Spermidine may mitigate age-induced deteriorations of the heart, brain, and hair by inducing autophagy and preserving telomere length — the protective endcaps of our chromosomes.

Chronological age is a substandard proxy for biological age, as seen by this cohort of 45-year-olds who varied widely in their rates of internal aging and organ dysfunction.

From antioxidant-rich plants to omega-3-loaded seafood to caloric restriction, there’s plenty you can eat — or avoid — to boost your chances of becoming a healthy centenarian.

Despite all of the advances that longevity research has made in recent years, metabolic changes and dysfunction are an under-studied piece of the aging puzzle.