NMN supplementation boosts the NAD+ pool in the intestine and activates the signaling pathways related to antioxidant, anti-inflammatory, and barrier functions that support healthy intestinal aging.

In a recent study, Buck Institute researchers demonstrate for the first time a direct link between dietary restriction, circadian rhythm, eye health, and lifespan in fruit flies.

Exercise triggers the release of tiny sacs (extracellular vesicles) containing an enzyme critical to synthesizing NAD+, promoting cellular crosstalk to improve health during aging. 

The compound crocin—found in saffron—benefits learning, memory, and social interaction in stressed mice by regulating an enzyme that produces NMN, a precursor to the vital molecule NAD+.